While the Spaniards were in Tlaxcala, a great plague broke out here in Tenochtitlan. It began to spread during the thirteenth month and lasted for seventy days, striking every where in the city and killing a vast number of our people. Sores erupted on our faces, our breasts, our bellies; we were covered with agonizing sores from head to foot.
The illness was so dreadful that no one could walk or move. The sick were so utterly helpless that they could only lie on their beds like corpses, unable to move their limbs or even their heads. They could not lie face down or roll from one side to the other. If they did move their bodies, they screamed with pain.
A great many died from this plague, and many others died of hunger. hey could not get up to search for food, and everyone else was too sick to care for them, so they starved to death in their beds.
Some people came down with a milder form of the disease; they suffered less than the others and made a good recovery. But they could not escape entirely. Their looks were ravaged, for wherever a sore broke out, it gouged an ugly pockmark in the skin. And a few of the survivors were left completely blind.
The first cases were reported in Cuatlan. By the time the danger was recognized, the plague was so well established that nothing could halt it, and eventually it spread all the way to Chalco. Then its virulence diminished considerably, though there were isolated cases for many months after. The first victims were stricken during the fiesta of Teotlecco and the faces of our warriors were not clean and free of sores until the fiesta of Panquetzaliztli.